GOLDGUT - M520 defines a new benchmark for intestinal repair, and domestic strains are entering a golden era.

Recently, the No. 3 tank at the Shanghai Oil Tank Art Center was illuminated by the flowing light and shadow of user stories from WonderLab, a brand under Wanyi Lan.

The steady breathing of a yoga teacher while stretching on the mat, the reassuring smile of a pregnant woman gently caressing her belly, the excitement of a beauty blogger after "saying goodbye to sensitive skin", the exhilaration of a skiing enthusiast after crossing the finish line...

These real and tangible moments intertwined with the scenes from the brand's short film "Smooth Sailing". On the screen, actress Jin Jing said with a smile, "Get yourself sorted out first, then you can handle life. Only when things go smoothly regularly can everything go well. Take WonderLab every day, and every day will be smooth."

At this moment, the images and reality formed an intertextual relationship, and the sharing session for WonderLab's 6th anniversary and the 66 Intestinal Health Festival kicked off amidst such resonance.

At the sharing session, WonderLab announced its first patented probiotic strain, GOLDGUT - M520, which can repair the four - layer intestinal barrier, and reshaped the golden intestinal health system from "temporary relief" to "systematic reconstruction".

As the concept of the "golden intestinal system" illuminated the night sky, the horn for the Chinese probiotic industry to march into the era of "systematic intestinal protection" sounded along with this celebration.

The Scientific Revolution of Four - Dimensional Barrier Repair

In China, nearly 90% of the population is suffering from intestinal problems. Whether it's office workers who sit for long hours and exercise little, fitness coaches with irregular diets and schedules, mothers whose rhythms are disrupted by parenting chores, or children whose intestinal functions are still developing, they may all experience a gradual build - up of intestinal burden due to minor imbalances in their daily habits.

The experiences of these individuals piece together the survival picture of hundreds of millions of people affected by intestinal problems. Intestinal discomfort is not only a warning signal from the body but also an invisible problem that lowers work efficiency, disrupts social status, and affects the quality of life.

When people instinctively seek probiotics for relief, they find that traditional solutions are stuck in the dilemma of treating the symptoms rather than the root cause. A long - standing pain point in the industry has always troubled consumers and practitioners: Most products on the market can only perform "partial repairs" for a single intestinal problem but cannot achieve "systematic reconstruction" of intestinal health.

As Liu Yanchen, the brand director of WonderLab, put it, "It's like fixing a badly damaged wooden barrel. Only one plank is repaired, but as long as there are planks that haven't been fixed, the whole barrel will still leak, and intestinal problems are difficult to completely improve."

The reason is that when traditional probiotic products focus on regulating the number of bacteria, a more fundamental problem is overlooked - the essence of intestinal health lies in the coordinated protection of the four - layer barrier.

At the ceremony, Professor Wang Xingguo, the vice - chairman of the Liaoning Nutrition Society and the vice - president of the Liaoning Dietitians Association, deeply analyzed the core logic of intestinal health: The intestine is not simply a digestive channel but a "four - layer shield" composed of the biological barrier, chemical barrier, mechanical barrier, and immune barrier.

The bacterial film of the biological barrier prevents the colonization of harmful bacteria; the mucus of the chemical barrier isolates external stimuli; the tight junctions of epithelial cells in the mechanical barrier prevent "intestinal leakage"; and the immune barrier is responsible for eliminating invaders. Any damage to one layer can trigger a chain reaction such as abdominal distension, inflammation, and a weakened immune system.

Therefore, to scientifically protect the intestine, starting from protecting the four - layer intestinal barrier and maintaining the stability of intestinal flora is becoming the core breakthrough in health management. In daily life, in addition to a balanced diet, it is also necessary to supplement key nutrients such as probiotics and dietary fiber.

"The balance of the intestinal barrier and intestinal flora is a systematic project. The earlier you start protecting, the higher the efficiency," emphasized Professor Wang Xingguo.

However, for a long time, the industry has lacked a solution that can comprehensively repair the four - layer intestinal barrier. The breakthrough upgrade of WonderLab's Small Blue Bottle Probiotic 4.0 is the key to solving this pain point.

WonderLab's Small Blue Bottle Probiotic 4.0 is equipped with the first patented probiotic strain, GOLDGUT - M520, designed to repair the four - layer intestinal barrier, and features an original "1 repair, 2 supplement, 3 accelerate" advanced system, providing a systematic solution for intestinal care.

It is reported that GOLDGUT - M520 can directly address the core pain points of the four - layer barrier. At the mechanical barrier level, it enhances the tightness of cells, completely blocking the "intestinal leakage" gaps and relieving abdominal pain and bloating; at the immune barrier level, it activates the defense system, enhancing the intestine's self - protection ability, like equipping the intestine with an "all - weather patrol team".

Secondly, for the biological barrier, GOLDGUT - M520 can increase the competitive advantage of beneficial bacteria by 1.2 times, suppressing the colonization of harmful bacteria and reconstructing the microbial ecosystem; for the chemical barrier, it stimulates the secretion of mucin by 1.77 times, coating the intestine with an "invisible waterproof layer" to block the invasion of pathogens.

In addition, through the coordinated repair of the four - layer barrier, GOLDGUT - M520 can create a positive cycle between the balance of intestinal flora and the improvement of barrier function, accelerating the reconstruction process of the intestine from "damaged" to the "golden state".

As the four - layer intestinal barrier stands firm like a solid fortress, office workers who were once tortured by intestinal problems, mothers troubled by intestinal discomfort, fitness enthusiasts disturbed by intestinal sensitivity, and children whose immune systems were dragged down by poor intestinal conditions... The focus, vitality, confidence, and laughter that were quietly taken away by intestinal problems, and the lives that were once stolen by the intestine, will all be restored through the systematic repair of GOLDGUT - M520.

The Road to Success - The R & D Marathon Behind 453 Breast Milk Samples

In the probiotic industry, there is a dilemma hidden in laboratory data.

Most strains are developed targeting the intestinal micro - environment of specific populations. When they enter different dietary scenarios, they often face challenges in adaptability. To truly achieve precise protection of intestinal health, one needs to find answers from a source that is more in line with natural laws. The research team of WonderLab finally set their sights on breast milk, the initial gift of life.

Breast milk is not just a carrier of nutrients. It is more like a dynamic ecosystem that delivers key bioactive factors for building the initial health of newborns. Research has found that each milliliter of breast milk contains about 1000 colony - forming units, mainly composed of Bifidobacterium and Lactobacillus. Like a well - trained "vanguard force", they migrate to the milk through the mother's gut - mammary gland axis and are vertically transmitted to the baby through breastfeeding, establishing the body's earliest intestinal flora.

These microorganisms occupy the intestinal ecological niche, stimulate the secretion of mucin, promote cell junctions, and regulate the immune system. They are the "founders" of the four - layer intestinal barrier in the early stages of life.

Breast milk - derived probiotics have unique cross - generational value for adult intestinal health. Their effects not only come from the physiological activity of the strains themselves but also carry the unique adaptability of mother - to - child vertical transmission. Breast milk - derived probiotics have natural host adaptability. Some probiotics can produce substances such as short - chain fatty acids and exopolysaccharides, which help the probiotics better colonize. At the same time, some breast milk - derived probiotics can make the intestinal epithelial cells tighter and even help relieve inflammation and improve allergies.

This natural wisdom made the team believe that breast milk - derived probiotics might be the key to solving the problem of strain adaptability. Therefore, WonderLab targeted the probiotic resources in breast milk, and a sample collection across the north and south of China began.

The researchers' footsteps extended from the grasslands of Inner Mongolia to the pastoral areas of Xinjiang, where nomadic people mainly have a high - protein and high - fat diet, and the intestinal flora needs to cope with a stronger digestive load. Then they went to the land of fish and rice in Hubei, where the humid climate and rice - growing culture have given rise to a dietary structure that favors carbohydrates and high - fiber foods, and the intestinal micro - environment emphasizes metabolic balance. Finally, they reached the urban area of Beijing.

453 milk samples from healthy mothers were carefully collected, refrigerated, and transported. Each sample carried the imprint of regional dietary culture, like a "Chinese dietary map" full of intestinal codes waiting to be deciphered.

The screening process was much more rigorous than expected. Thousands of lactic acid bacteria were isolated from the samples. First, they had to pass the "survival test": the strong acid environment of gastric acid and the alkaline test of bile salts. Most strains were eliminated in this round.

The "survivors" also had to undergo a "genetic physical examination", and strains with potential risks were eliminated through genomic scanning. Finally, there was the ultimate challenge of the "four - layer barrier test field": micro - ecological reconstruction, mucus layer repair, tight junctions of intestinal epithelial cells, and immune correction.

Finally, in this continuous "elimination round", the star strain GOLDGUT - M520 showed outstanding ability to coordinately repair the four - layer barrier, which was a height that single strains in the past industry could hardly reach. In addition to increasing the competitive advantage of beneficial bacteria by 1.2 times and stimulating the secretion of mucin by 1.77 times as mentioned before, it can also increase the expression of tight - junction proteins by 1.84 times and enhance the activity of immune signaling molecules by 2.62 times, activating the intestine's "defense system".

Xue Hui, an associate professor at the College of Food Science and Engineering of Hainan University, said, "Research shows that this strain can significantly increase the expression of intestinal tight - junction proteins ZO - 1 and Occludin, enhancing the intestinal barrier function. At the same time, animal experiments further confirm its improvement effect on multiple scenarios such as inflammatory bowel disease, functional constipation, and allergic rhinitis, providing new evidence for probiotics to regulate intestinal health and immune balance."

However, the R & D team did not stop at the laboratory data. To verify the universality of GOLDGUT - M520, a "northern strain, southern verification" marathon was immediately launched. In the coconut groves of the Hainan Free Trade Port, the Tropical Probiotic Joint Research Center jointly established by WonderLab and Hainan University was inaugurated. Researchers, together with authoritative medical institutions such as the Hainan Provincial People's Hospital, conducted a randomized double - blind clinical trial among hundreds of volunteers.

From the northern grasslands to the tropical islands, from herdsmen with a high - protein diet to southern residents who prefer seafood, they wanted to test whether this strain could stably play its repair function across climate zones and dietary differences.

Verifying the efficacy among people in different climate zones and with different living habits fully demonstrates WonderLab's independent R & D strength and full - scale adaptability.

From sample collection in multiple regions such as Xinjiang, Inner Mongolia, Hubei, and Beijing, to laboratory verification in Hainan, and then to formula optimization at the R & D center in Shenzhen, it finally became the Small Blue Bottle Probiotic in consumers' hands. In the persistent exploration of the R & D link of "precisely adapting to intestinal needs", WonderLab's R & D team completed a strain R & D marathon across vast distances.

From the Iteration of the "Small Blue Bottle Probiotic" to the Golden Age of Self - Developed Strains

Let's rewind the clock to 2019. In the field of health and nutrition at that time, although many brands had emerged, there were still large gaps to be filled in meeting the new needs of the younger generation in areas such as sports nutrition, intestinal health, and sleep health.

In an era of fast - paced and quality - oriented life, young people are eager to improve their health in a convenient and efficient way. Thus, WonderLab was born in this context and officially launched the 1.0 version of the Small Blue Bottle Probiotic in 2020.

When the 1.0 version was launched, the probiotic market was still in its development stage, and many products relied on imported strains. Through extensive market research in the early stage, WonderLab established an advanced and unique R & D platform in China. Its iconic Small Blue Bottle Probiotic, once launched, created ripples like a stone thrown into a lake, laying the initial influence in the probiotic market.

With the in - depth research on intestinal health and the continuous improvement of consumer demand, WonderLab launched the Small Blue Bottle Probiotic 2.0 in 2022. This upgrade optimized the formula and added stachyose. In 2023, the Small Blue Bottle Probiotic reached the crucial 3.0 version. This generation of products combined a scientific formula and selected strains, introducing the patented strain Bi - 07 and selecting 6 "high - activity elite bacteria" from a library of over 15,000 strains.

In 2025, as mentioned before, the Small Blue Bottle Probiotic 4.0 brought the more revolutionary GOLDGUT - M520.

As a strain verified by cell - level evidence - based research, as a strain included in the Institute of Microbiology of the Chinese Academy of Sciences, and as the first domestic self - developed strain to achieve "simultaneous repair of the four - dimensional barrier", the emergence of GOLDGUT - M520 injected core impetus into the iteration of the Small Blue Bottle Probiotic.

More significantly, the R & D of GOLDGUT - M520 broke the situation where the mainstream strains relied on imports. Chinese domestic self - developed strains can support the long - term development of the industry with strength comparable to that of Europe and the United States, bringing better health management solutions to consumers.

As the Small Blue Bottle Probiotic evolved from the "industry pioneer" of version 1.0 to the "barrier architect" of version 4.0, WonderLab's six - year iteration history is a microcosm of the Chinese probiotic industry. The unveiling of the "golden intestinal system" marks the shift of the battle from "domestic substitution" to "standard output".

In this process of breakthrough and innovation, WonderLab achieved the remarkable result of selling 600 million bottles across the entire network. In April 2024, the market position confirmation certificate issued by Frost & Sullivan also clearly established WonderLab's industry ranking as the "No. 1 in Chinese probiotic sales".

Today, the iteration history of the Small Blue Bottle Probiotic is not only a record of the brand's growth but also a microcosm of WonderLab's independent R & D strength. As GOLDGUT - M520 with the original life force of breast milk enters thousands of families and the "golden intestinal system" defines a new industry standard, the golden age of WonderLab's self - developed strains has begun.

As the lights at the ceremony gradually dimmed, the images of user stories on the tank wall became clearer. These intestinal lives changed by GOLDGUT - M520 are vivid illustrations of WonderLab's R & D strength. Supported by science and based on evidence - based research, in the coordinate system of independent innovation, WonderLab will build a more solid clinical evidence - based foundation, more precise intestinal health solutions, and a more complete self - developed strain R & D system, so that the wisdom of intestinal health can build a solid intestinal barrier for more people in the dawn and dusk of the laboratory and the cycles of the industry.